基础医学与临床 ›› 2014, Vol. 34 ›› Issue (12): 1710-1713.

• 短篇综述 • 上一篇    下一篇

葡萄糖调节蛋白78在肝脏不同应激损伤时的作用

胡深1,张洪义2   

  1. 1. 安徽医科大学空军临床学院
    2. 中国人民解放军空军总医院
  • 收稿日期:2014-01-16 修回日期:2014-05-25 出版日期:2014-12-05 发布日期:2014-11-25
  • 通讯作者: 张洪义 E-mail:zhhyiyi1487@163.com
  • 基金资助:
    全军医学科技“十二五”科研项目

Research progress of glucose regulated protein78 and liver stress

  • Received:2014-01-16 Revised:2014-05-25 Online:2014-12-05 Published:2014-11-25

摘要: 葡萄糖调节蛋白78(GRP78),又称为免疫结合球蛋白(Bip),是细胞应激时产生的应激蛋白。作为热休克蛋白70家族的一员,在应激条件下,GPR78蛋白通过在内质网中协助多聚体蛋白质复合物的形成,起到保护和维持细胞正常代谢作用。肝脏是机体物质代谢的重要器官,各种酶和蛋白的生化加工厂,故应激反应下肝细胞GRP78/ Bip的表达显得尤为重要。

关键词: 葡萄糖调节蛋白78, 肝脏, 热应激, 氧化应激, 内质网应激

Abstract: Glucose regulated protein78,GRP78,called immunoglobulin binding protein, is a highly conserved stress protein which is produced by the organism in the stressor stimulation. GRP-78 protein appears to play a role in helping in the assembly of multimeric proteincomplexes in the endoplasmic reticulum (ER).The expression of GRP78/Bip plays a particularly vital role of dealing with the stress response in the liver which is important organ of the body metabolismand biochemical processing factory of various enzyme.

Key words: Glucose regulated protein78, liver, Heat Stress, Oxidative Stress, Endoplasmic Reticulum Stress