基础医学与临床 ›› 2012, Vol. 32 ›› Issue (4): 457-460.

• 短篇综述 • 上一篇    

肿瘤干细胞在肿瘤转移中的作用与相关机制的研究进展

朱玉珍1,符达2,马雨水2   

  1. 1. 同济大学
    2. 复旦大学
  • 收稿日期:2011-05-31 修回日期:2011-10-09 出版日期:2012-04-05 发布日期:2012-03-21
  • 通讯作者: 符达 E-mail:fu800da900@yahoo.com.cn
  • 基金资助:
    中国博士后基金

The effect and related mechanism of cancer stem cell in tumor metastasis: new perspective and progress

  • Received:2011-05-31 Revised:2011-10-09 Online:2012-04-05 Published:2012-03-21

摘要: 肿瘤转移是肿瘤患者死亡的主要原因。目前国内外对肿瘤转移的机制已进行了系统而深入的探索。随着肿瘤干细胞概念的提出和相关领域的深入研究,肿瘤干细胞作为肿瘤转移的最佳候选细胞的观点正逐渐被人们接受。肿瘤干细胞的致瘤能力已经在白血病及其他许多肿瘤中得到证实,然而肿瘤干细胞在肿瘤转移中起的作用仍不十分清楚。目前和肿瘤转移过程相关的分子机制包括:上皮间质转化(Epithelial–mesenchymal transition, EMT)、肿瘤微环境、血管生成机制等。近年来实验也显示上述机制在肿瘤干细胞转移过程中起到不可低估的作用。本文就肿瘤干细胞在肿瘤转移中的作用及相关机制的进展做一综述。

关键词: 肿瘤干细胞, 转移, 上皮间质转化, 微环境, 血管生成

Abstract: Metastasis is the major cause of death for cancer patients. Further insights have been put into the biology of metastasis. Recently, with the growing support for the cancer stem cell (CSCs) hypothesis and probing into the properties of CSC and related field, more and more evidences suggest CSCs as candidates for mediating metastatic progression. The importance of CSCs in tumor-initiation has been firmly established in leukemia and other solid tomors. However, the role of CSCs in multistage cancer progression, particularly with respect to metastasis, has not been well-defined. Studies have suggested the epithelial-mesenchymal transition (EMT), tumor microenvironment and angiogenesis in regulating cancer metastasis. Current research has also highlighted the above related mechanism in mediating CSC metastasis. The purpose of this review is to discuss recent advances in the field of CSC metastasis and related mechanism.

Key words: cancer stem cell, metastasis, epithelial-mesenchymal transition, tumor microenvironment, angiogenesis

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