基础医学与临床 ›› 2011, Vol. 31 ›› Issue (1): 101-103.

• 短篇综述 • 上一篇    下一篇

Ⅱ类组蛋白去乙酰化酶与临床

王红晖,万玉民,李莹辉   

  1. 中国航天员中心
  • 收稿日期:2010-01-22 修回日期:2010-04-15 出版日期:2011-01-05 发布日期:2011-01-05
  • 通讯作者: 王红晖

Class II Members of HDACs and Clinic

WANG Hong-hui 1,WAN Yu-min 2,LI Ying-hui 2   

  1. 1. China Astronaut Research and Training Center2.
  • Received:2010-01-22 Revised:2010-04-15 Online:2011-01-05 Published:2011-01-05
  • Contact: WANG Hong-hui

摘要: Ⅱ类组蛋白去乙酰化酶及其相互作用分子在与临床相关的生物学过程中发挥着重要作用。近年来发现,Ⅱ类组蛋白去乙酰化酶与临床心血管疾病、呼吸系统疾病和骨软骨疾病的发生,肿瘤进展以及药学研究等密切相关。本文就Ⅱ类HDACs与临床的关系进行了综述。

关键词: 组蛋白, 乙酰化修饰, 组蛋白去乙酰化酶, 临床

Abstract: Class II members of HDACs and their interactional moleculars plays an important role in biological processes of clinical relevance. Resent reports revealed that the development of cardiovascular diseases, respiratory system and bone diseases, the progress of the tumor and clinical pharmaceutical research have been directly or indirectly correlated with Class II members of HDACs.This review focused on the relationship between the HDACs and clinical diseases.