关键词: 尿酸, 高尿酸血症, 代谢综合征

Abstract: Objective To evaluate the relationship between serum uric acid and metabolic syndrome in Beijing adults. Methods We conducted a study in a cohort of 2174 individuals (1280 men and 894 women) who participated in annual health examinations at the Peking Union Medical College Hospital from September to December 2005. We analysed the relationship between serum uric acid and metabolic syndrome. Results Serum uric acid levels increased in groups of individuals with more components of metabolic syndrome. The risk of metabolic syndrome showed a graded increase according to serum uric acid levels, the risk of metabolic syndrome (odds ratio, 95% CI) in sex-specific quartiles of serum uric acid was 1.90 (1.26～2.86), 2.66 (1.79～3.94), and 5.06 (3.35～7.65) in men, and 1.66 (1.03～2.68), 2.33 (1.42～3.82), and 4.65 (2.91～7.43) in women. Conclusion Serum uric acid level is an independent risk factors associated with metabolic syndrome. Further studies are needed to explore the mechanism for the close relationship between them.

Key words: Uric acid, Hyperuremia, Metabolic syndrome