肾上皮细胞损伤与肾结石Randall斑块形成

doi:10.16352/j.issn.1001-6325.2022.09.1454

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (9): 1454-1458.doi: 10.16352/j.issn.1001-6325.2022.09.1454

肾上皮细胞损伤与肾结石Randall斑块形成

杨雄¹, 靳潇潇¹, 何文强^2*

1. 河南中医药大学, 河南郑州 450046;
2. 河南中医药大学第一附属医院, 河南郑州 450003

收稿日期:2021-06-23 修回日期:2021-10-09 出版日期:2022-09-05 发布日期:2022-09-02
通讯作者: 1392423546@qq.com
基金资助:
河南省重点研发与推广专项(科技攻关) (182102310059)

Injury of renal epithelial cell and the formation of Randall's plaque in kidney stones

YANG Xiong¹, JIN Xiao-xiao¹, HE Wen-qiang^2*

1. Henan University of Traditional Chinese Medicine,Zhengzhou 450046;
2. The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450003,China

Received:2021-06-23 Revised:2021-10-09 Online:2022-09-05 Published:2022-09-02

摘要/Abstract

摘要： 肾结石具有较高的发病率和复发率,是泌尿外科常见的疾病之一。目前Randall斑块学说是一种被普遍接受的肾结石形成机制, Randall斑块相关研究对肾结石的防治有重要意义,肾上皮细胞损伤促进Randall斑块形成。本文从肾上皮细胞成骨样改变、活性氧与氧化应激,巨噬细胞的吞噬,非编码RNA改变的研究进展进行综述。

关键词: Randall斑块, 成骨样改变, 巨噬细胞, 活性氧, 炎性反应

Abstract: Kidney stone has a high incidence and recurrence rate, which is one of the common diseases in urology.At present, Randall's plaque theory is a widely accepted mechanism for the formation of kidney stones. Studies on Randall's plaque are of great significance for the prevention and treatment of kidney stones. Renal epithelial cell damage promotes the formation of Randall's plaque.In this paper, the research progress of osteogenic changes in renal epithelial cells, reactive oxygen species and oxidative stress, phagocytosis of macrophages, and non-coding RNA changes are reviewed.

Key words: Randall's plaque, osteoblastic changes, macrophages, reactive oxygen species, inflammation

中图分类号:

R320.2

杨雄, 靳潇潇, 何文强. 肾上皮细胞损伤与肾结石Randall斑块形成[J]. 基础医学与临床, 2022, 42(9): 1454-1458.

YANG Xiong, JIN Xiao-xiao, HE Wen-qiang. Injury of renal epithelial cell and the formation of Randall's plaque in kidney stones[J]. Basic & Clinical Medicine, 2022, 42(9): 1454-1458.

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肾上皮细胞损伤与肾结石Randall斑块形成

Injury of renal epithelial cell and the formation of Randall's plaque in kidney stones

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