Page 18 - Demo

%u4e00%u7c7b%u65b0%u7684%u5177%u6709 %u03c3%uff11%uff32%uff0f%uff2d%uff2f%uff32%u53cc%u9776%u70b9%u6d3b%u6027%u7684 %uff11%ue011%uff4f%uff58%uff41%ue011%uff14%uff0c%uff19%ue011%uff44%uff49%uff41%uff5a%uff41%uff53%uff50%uff49%uff52%uff4f%uff3b%uff15%ue010%uff15%uff3d%uff55%uff4e%uff44%uff45%uff43%uff41%uff4e%uff45%u884d%u751f%u7269%u3002%u5176%u4e2d%uff0c%uff25%uff33%uff34%uff17%uff13%uff15%uff10%uff12%uff08%uff11%uff15%uff0c%u56fe %uff17%uff09%u4e0d%u540c%u4e8e%u4f20%u7edf%u963f%u7247%u7c7b%u836f%u7269%u7f9f%u8003%u916e%uff0c%u5176%u5177%u6709%u76f8%u5bf9%u66f4%u5f31%u7684%u526f%u4f5c%u7528%uff0c%u5305%u62ec%u80c3%u80a0%u9053%u8815%u52a8%u6291%u5236%u3001%u7eb3%u6d1b%u916e%u8bf1%u5bfc%u7684%u6212%u65ad%u75c7%u72b6%u7b49%u3002%u76ee%u524d %uff25%uff33%uff34%uff17%uff13%uff15%uff10%uff12%u6b63%u5904%u4e8e%u2160%u671f%u4e34%u5e8a%u8bd5%u9a8c%u9636%u6bb5%uff0c%u4e5f%u662f%u7b2c%u4e00%u4e2a%u8fdb%u5165%u4e34%u5e8a%u8bd5%u9a8c%u7684 %uff2d%uff2f%uff32%uff0f%u03c3%uff11%uff32%u53cc%u529f%u80fd%u5206%u5b50%uff3b%uff15%uff14%uff3d%u3002%u8fd1%u5e74%u6765%uff0c%u672c%u8bfe%u9898%u7ec4%u62a5%u9053%u4e86%u591a%u4e2a%u7cfb%u5217%u7684%u53cc%u529f%u80fd %uff2d%uff2f%uff32%u548c %u03c3%uff11%uff32%u914d %u4f53%uff0c%u5305 %u62ec %u5316 %u5408 %u7269 %uff11%uff16%uff5e%uff11%uff18%u7b49%uff3b%uff15%uff15%ue011%uff15%uff17%uff3d %uff08%u56fe %uff17%uff09%u3002 %u5176 %u4e2d%u5316%u5408%u7269 %uff11%uff18%u4e3a %uff12%uff10%uff12%uff14%u5e74%u62a5%u9053%u7684%u65b0%u567b%u5429%u54cc%u55ea%u9170%u80fa%u884d%u751f%u7269%uff0c%u5728%u918b%u9178%u626d%u4f53%u5b9e%u9a8c%uff08%uff25%uff24%uff15%uff10 %uff1d%uff13%ue010%uff18%uff13%uff4d%uff47%u00b7%uff4b%uff47%uff0d%uff11%uff09%u548c%u5361%u62c9%u80f6%u81f4%u708e%u6027%u75bc%u75db%u6a21%u578b%uff08%uff25%uff24%uff15%uff10 %uff1d%uff15%ue010%uff12%uff13%uff4d%uff47%u00b7%uff4b%uff47%uff0d%uff11%uff09%u4e2d%u5747%u8868%u73b0%u51fa%u8f83%u5f3a%u7684%u9547%u75db%u4f5c%u7528%u3002%u4e0a%u8ff0%u5316%u5408%u7269%u8868%u660e%uff0c%u5177%u6709 %uff2d%uff2f%uff32%uff0f%u03c3%uff11%uff32%u53cc%u9776%u70b9%u6d3b%u6027%u7684%u5316%u5408%u7269%u5bf9%u4e2d%u81f3%u91cd%u5ea6%u75bc%u75db%u5177%u6709%u826f%u597d%u7684%u9547%u75db%u4f5c%u7528%u548c%u66f4%u9ad8%u7684%u5b89%u5168%u6027%u3002%u5176%u4ed6%u57fa%u4e8e %u03c3%uff11%uff32%u548c %uff2d%uff2f%uff32%u53cc%u9776%u70b9%u7684%u9547%u75db%u836f%u7269%u7814%u7a76%u8fdb%u5c55%u53ef%u53c2%u8003 %uff12%uff10%uff12%uff11%u548c %uff12%uff10%uff12%uff14%u5e74%u672c%u8bfe%u9898%u7ec4%u53d1%u8868%u7684%u7efc%u8ff0%uff3b%uff15%uff18%ue011%uff15%uff19%uff3d%u3002NONFO15(EST73502) FN NO16(HKC-126) ONNFO17(Tao-191)N NNSO18Ki %u00b5 = 64 nmol%u00b7L-1Ki%u03c31 = 118 nmol%u00b7L-1Ki %u00b5 = 4.3 nmol%u00b7L-1Ki%u03c31 = 19.4 nmol%u00b7L-1Ki %u00b5 = 6.5 nmol%u00b7L-1Ki%u03c31 = 35.7 nmol%u00b7L-1EC50 %u00b5 160 nmol%u00b7L-1Ki%u03c31==44.7 nmol%u00b7L-1%uff25%uff23%uff15%uff10%u03bc%uff0d%u5316%u5408%u7269%u4e0e %u03bc%u963f%u7247%u53d7%u4f53%u7ed3%u5408%u65f6%u4ea7%u751f %uff15%uff10%uff05%u6700%u5927%u751f%u7269%u6548%u5e94%u7684%u6d53%u5ea6%uff1b%uff2b%uff49%u03c3%uff11%uff0d%u5316%u5408%u7269%u5bf9 %uff33%uff49%uff47%uff4d%uff41%uff0d%uff11%u53d7%u4f53%u7684%u7ed3%u5408%u4eb2%u548c%u529b%u3002%u56fe %uff17 %u03bc%u963f%u7247%u53d7%u4f53%uff0f%uff33%uff49%uff47%uff4d%uff41%ue011%uff11%u53d7%u4f53%uff08%uff2d%uff2f%uff32%uff0f%u03c3%uff11%uff32%uff09%u53cc%u9776%u70b9%u6d3b%u6027%u914d%u4f53%uff3b%uff15%uff13%ue011%uff15%uff17%uff3d%uff12%ue010%uff16 %uff2d%uff2f%uff32%uff0f%uff23%uff22%uff32%u53cc%u9776%u70b9%u5316%u5408%u7269%u5185%u6e90%u6027%u5927%u9ebb%u7d20%u901a%u8fc7%u4e2d%u8111%u5bfc%u6c34%u7ba1%u5468%u56f4%u7070%u8d28%u3001%u810a%u9ad3%u80cc%u89d2%u4ee5%u53ca%u80cc%u6839%u795e%u7ecf%u8282%u7684%u5927%u9ebb%u7d20%u53d7%u4f53%u53d1%u6325%u6297%u75db%u4f5c%u7528%uff3b%uff16%uff10%uff3d%u3002%uff23%uff22%uff32%u5305%u62ec %uff23%uff22%uff11%u53d7%u4f53%uff08%uff23%uff22%uff11%uff32%uff09%u548c %uff23%uff22%uff12%u53d7%u4f53%uff08%uff23%uff22%uff12%uff32%uff09%u4e24%u79cd%u4e3b%u8981%u4e9a%u578b%uff0c%u5e7f%u6cdb%u8868%u8fbe%u4e8e%u4e2d%u67a2%u548c%u5468%u56f4%u795e%u7ecf%u7ec4%u7ec7%u4ee5%u53ca%u975e%u795e%u7ecf%u7ec4%u7ec7%uff3b%uff16%uff11%uff3d%u3002%uff23%uff22%uff32%u548c%u963f%u7247%u53d7%u4f53%u5728%u4e2d%u67a2%u795e%u7ecf%u7cfb%u7edf%u7684%u591a%u4e2a%u533a%u57df%u5171%u8868%u8fbe%uff0c%u5e76%u5171%u540c%u53c2%u4e0e%u8c03%u8282%u75bc%u75db%u611f%u77e5%u3001%u60c5%u7eea%u7b49%u751f%u7406%u8fc7%u7a0b%uff3b%uff16%uff12%uff3d%u3002%uff23%uff22%uff32%u548c %uff2d%uff2f%uff32%u5747%u80fd%u591f%u8c03%u8282 %uff43%uff21%uff2d%uff30%u6d3b%u6027%u3001%u6fc0%u6d3b %uff23%uff41%uff12%uff0b%u901a%u9053%u4ee5%u53ca%u8c03%u63a7%u795e%u7ecf%u9012%u8d28%u7684%u91ca%u653e%uff3b%uff16%uff13%uff3d%u3002%u4e34%u5e8a%u524d%u548c%u4e34%u5e8a%u7814%u7a76%u8868%u660e%uff0c%u963f%u7247%u548c%u5927%u9ebb%u7d20%u7cfb%u7edf%u4e4b%u95f4%u7684%u4ea4%u4e92%u4f5c%u7528%u5728%u63a7%u5236%u75bc%u75db%u65b9%u9762%u5c55%u73b0%u51fa%u534f%u540c%u4f5c%u7528%uff3b%uff16%uff14%uff3d%u3002%u56e0%u6b64%uff0c%u5f00%u53d1 %uff2d%uff2f%uff32%uff0f%uff23%uff22%uff32%u53cc%u529f%u80fd%u6fc0%u52a8%u5242%u53ef%u80fd%u6210%u4e3a%u6cbb%u7597%u795e%u7ecf%u6027%u75bc%u75db%u7684%u65b0%u7b56%u7565%u3002%u5316%u5408%u7269 %uff2f%uff23%uff30%uff10%uff10%uff12%uff08%uff11%uff19%uff0c%u56fe %uff18%uff09%u7ed3%u5408%u4e86 %uff2d%uff2f%uff32%u6fc0%u52a8%u5242 %uff24%uff21%uff2c%uff24%uff21%u548c %uff23%uff22%uff11%uff32%u6fc0%u52a8%u5242%u7684%u80bd%u5e8f%u5217 %uff36%uff24%ue011%uff28%uff50%u03b1%ue011%uff2e%uff28%uff12%u7684%u7ed3%u6784%u7279%u5f81%uff0c%u5177%u6709%uff2d%uff2f%uff32%uff0f%uff23%uff22%uff11%uff32%u6df7%u5408%u6fc0%u52a8%u5242%u6d3b%u6027%uff3b%uff16%uff15%uff3d%u3002%uff2f%uff23%uff30%uff10%uff10%uff12%u5728%u4e59%u9178%u626d%u4f53%u5b9e%u9a8c%uff08%uff25%uff24%uff15%uff10%uff1d%uff10%ue010%uff10%uff10%uff16%uff19%uff4e%uff4d%uff4f%uff4c%u00b7%uff4b%uff47%uff0d%uff11%uff09%u3001%u89d2%u53c9%u83dc%u80f6%u8bf1%u5bfc%u7684%u673a%u68b0%u5f02%u5e38%u6027%u75bc%u75db %uff08%uff25%uff24%uff15%uff10 %uff1d%uff10%ue010%uff17%uff16%uff4e%uff4d%uff4f%uff4c%u00b7 %uff4b%uff47%uff0d%uff11%uff09%u548c %u70ed %u75db %u89c9 %u8fc7 %u654f %uff08%uff25%uff24%uff15%uff10 %uff1d%uff10%ue010%uff11%uff13%uff4e%uff4d%uff4f%uff4c%u00b7%uff4b%uff47%uff0d%uff11%uff09%u5b9e%u9a8c %u4e2d %u53d1 %u6325 %u51fa %u5f3a %u9547 %u75db %u4f5c %u7528%u3002%uff24%uff56%uff4f%uff52?%uff43%uff53%uff4b%u00f3%u7b49%uff3b%uff16%uff16%uff3d%u5c06 %uff23%uff22%uff11%uff32%uff0f%uff23%uff22%uff12%uff32%u6fc0%u52a8%u5242 %uff2a%uff37%uff28%ue011%uff10%uff11%uff18%u4e0e%u963f%u7247%u7c7b%u9547%u75db%u836f%u7f9f%u8003%u916e%u5076%u8054%u8bbe%u8ba1%u4e86%u4e00%u7cfb%u5217%u53cc%u9776%u70b9%u6fc0%u52a8%u5242%uff0c%u5176%u4e2d%u5316%u5408%u7269 %uff12%uff10%uff08%u56fe %uff18%uff09%u5177%u6709 %uff2d%uff2f%uff32%uff0f%uff23%uff22%uff32%u53cc%u9776%u70b9%u6d3b%u6027%uff0c%u5e76%u4e14%u5728%u5927%u9f20%u6162%u6027%u9aa8%u5173%u8282%u708e%u75bc%u75db%u6a21%u578b%u4e2d%u8868%u73b0%u51fa%u4e0e%u9633%u6027%u836f%u7f9f%u8003%u916e%u76f8%u5f53%u7684%u9547%u75db%u6d3b%u6027%u3002%uff2d%uff2f%uff32%uff0f%uff23%uff22%uff32%u53cc%u9776%u70b9%u6d3b%u6027%u5316%u5408%u7269%u5728%u6cbb%u7597%u795e%u7ecf%u6027%u75bc%u75db%u65b9%u9762%u7684%u6cbb%u7597%u6f5c%u529b%u4ecd%u672a%u5f97%u5230%u5145%u5206%u63a2%u7d22%uff0c%u9700%u8981%u66f4%u591a%u9ad8%u8d28%u91cf%u7684%u7814%u7a76%u6765%u8bc4%u4f30%u5176%u7597%u6548%u548c%u5b89%u5168%u6027%u300220HONH OHNONH HNNHOHNONOHOOO NH HNOHNONH2NH2NH2NH2ONHHNOO H2NH2N19 (OCP002)Ki%u00b5=29.3 %u00b5mol%u00b7L-1Ki CBR=1.0-10.0 %u00b5mol%u00b7L-1Ki%u00b5=18.0 %u00b5mol%u00b7L-1Ki%u00b5CBR=12.0 %u00b5mol%u00b7L-1OCP002(1 and 10 %u00b5mol%u00b7L-1) increased the ERK1/2 phosphorylation in CB1-CHO cellsNNHOOOH OHN NH OHNNHOOOMeN OHNONHNO O%uff2b%uff49%uff23%uff22%uff32%uff0d%u5316%u5408%u7269%u5bf9%u5927%u9ebb%u7d20%u53d7%u4f53%u7684%u7ed3%u5408%u4eb2%u548c%u529b%u3002%u56fe %uff18 %u03bc%u963f%u7247%u53d7%u4f53%uff0f%u5927%u9ebb%u7d20%u53d7%u4f53%uff08%uff2d%uff2f%uff32%uff0f%uff23%uff22%uff32%uff09%u53cc%u9776%u70b9%u6d3b%u6027%u914d%u4f53%uff3b%uff16%uff15%ue011%uff16%uff16%uff3d%uff12%ue010%uff17 %uff2d%uff2f%uff32%uff0f%uff2e%uff26%uff30%uff30%uff32%u53cc%u9776%u70b9%u5316%u5408%u7269%u795e%u7ecf%u80bd %uff26%uff26%uff08%uff4e%uff45%uff55%uff52%uff4f%uff50%uff45%uff50%uff54%uff49%uff44%uff45%uff26%uff26%uff0c%uff2e%uff30%uff26%uff26%uff09%u662f%u4e00%u79cd%u5728%u54fa%u4e73%u52a8%u7269%u4f53%u5185%u666e%u904d%u5b58%u5728%u7684%u516b%u80bd%uff0c%uff2e%uff30%uff26%uff26%u901a%u8fc7%u4e0e%u4e24%u79cd%u4e9a%u578b%u53d7%u4f53 %uff2e%uff30%uff26%uff26%uff11%u548c%uff2e%uff30%uff26%uff26%uff12%u7ed3%u5408%u53d1%u6325%u4f5c%u7528%uff3b%uff16%uff17%uff3d%u3002%u7814%u7a76%u8868%u660e%uff0c%uff2e%uff30%uff26%uff26%u662f%u4e00%u79cd%u5185%u6e90%u6027%u7684%u963f%u7247%u8c03%u8282%u80bd%uff0c%u5bf9%u963f%u7247%u7c7b%u7269%u8d28%u5f15%u8d77%u7684%u9547%u75db%u6548%u679c%u5177%u6709%u53cc%u5411%u8c03%u8282%u4f5c%u7528%uff0c%u5728%u810a%u9ad3%u4ee5%u4e0a%u6c34%u5e73%uff0c%u5177%u6709%u6297%u963f%u7247%u7279%u6027%uff0c%u800c%u5728%u810a%u9ad3%u6c34%u5e73%u5219%u8868%u73b0%u00b7%uff12%uff11%uff11%uff11%u00b7%u4e2d%u56fd%u836f%u5b66%u6742%u5fd7 %uff12%uff10%uff12%uff14%u5e74 %uff11%uff11%u6708%u7b2c %uff15%uff19%u5377%u7b2c %uff12%uff12%u671f %uff23%uff48%uff49%uff4e%uff30%uff48%uff41%uff52%uff4d%uff2a%uff0c%uff12%uff10%uff12%uff14%uff2e%uff4f%uff56%uff45%uff4d%uff42%uff45%uff52%uff0c%uff36%uff4f%uff4c%ue010%uff15%uff19%uff2e%uff4f%ue010%uff12%uff12