Page 17 - Demo

O HO ONOO6 (BU10038)O HO OMeNHOH4 (Buprenorphine)NONH5 (Cebranopadol)FNNOS NHH2NOO7 (AT-121)Ki %u00b5 = 0.86 nmol%u00b7L-1Ki NOP = 14.8 nmol%u00b7L-1Ki %u00b5 = 16.49 nmol%u00b7L-1Ki NOP = 3.67 nmol%u00b7L-1Ki %u00b5 = 0.7 nmol%u00b7L-1Ki NOP = 0.9 nmol%u00b7L-1Ki %u00b5 = 1.52 nmol%u00b7L-1Ki NOP = 77.4 nmol%u00b7L-1Ki %u03b4 = 6.13 nmol%u00b7L-1Ki %u03ba = 2.50 nmol%u00b7L-1NNHClClO8 (BPR1M97)Ki %u00b5 = 1.8 nmol%u00b7L-1Ki NOP = 4.2 nmol%u00b7L-1FN HN HNOCl9Ki %u00b5 = 0.4 nmol%u00b7L-1Ki NOP = 0.2 nmol%u00b7L-1%uff2b%uff49%uff2e%uff2f%uff30%uff0d%u5316%u5408%u7269%u5bf9%u5b64%u5561%u80bd%u53d7%u4f53%u7684%u7ed3%u5408%u4eb2%u548c%u529b%uff1b%uff2b%uff49%u03b4%uff0d%u5316%u5408%u7269%u5bf9 %u03b4%u963f%u7247%u53d7%u4f53%u7684%u7ed3%u5408%u4eb2%u548c%u529b%uff1b%uff2b%uff49%u03ba%uff0d%u5316%u5408%u7269%u5bf9 %u03ba%u963f%u7247%u53d7%u4f53%u7684%u7ed3%u5408%u4eb2%u548c%u529b%u3002%u56fe %uff14 %u03bc%u963f%u7247%u53d7%u4f53%uff0f%u5b64%u5561%u80bd%u53d7%u4f53%uff08%uff2d%uff2f%uff32%uff0f%uff2e%uff2f%uff30%uff09%u53cc%u9776%u70b9%u6d3b%u6027%u914d%u4f53%uff3b%uff12%uff16%uff0c%uff12%uff19%ue011%uff13%uff14%uff3d12 (SRI-22141) NNO O HNNOOOHN NONH2OOH11(SW-LJ-11)Ki %u00b5 = 0.31 nmol%u00b7L-1Ki %u03b4 = 0.65 nmol%u00b7L-1Ki %u00b5 = 19.70 nmol%u00b7L-1Ki %u03b4 = 5.10 nmol%u00b7L-110(5m)Ki %u00b5 = 0.91 nmol%u00b7L-1Ki %u03b4 = 5.30 nmol%u00b7L-1HNONH2 OHOnPr HO N ONClO%u56fe %uff15 %u03bc%u963f%u7247%u53d7%u4f53%uff0f%u03b4%u963f%u7247%u53d7%u4f53%uff08%uff2d%uff2f%uff32%uff0f%uff24%uff2f%uff32%uff09%u53cc%u9776%u70b9%u6d3b%u6027%u914d%u4f53%uff3b%uff14%uff11%ue011%uff14%uff13%uff3d%uff12%ue010%uff14 %uff2d%uff2f%uff32%uff0f%uff2b%uff2f%uff32%u53cc%u9776%u70b9%u5316%u5408%u7269%u5355%u9776%u70b9 %uff2b%uff2f%uff32%u6fc0%u52a8%u5242%u5177%u6709%u9547%u75db%u4f5c%u7528%uff0c%u7279%u522b%u662f%u9488%u5bf9%u5185%u810f%u75bc%u75db%u6a21%u578b%uff0c%u4f46%u540c%u6837%u4f34%u6709%u8bb8%u591a%u4e0d%u826f%u53cd%u5e94%uff0c%u5982%u7126%u8651%u548c%u591a%u5c3f%u7b49%uff3b%uff14%uff14%uff3d%u3002%u7136%u800c%uff0c%uff2b%uff2f%uff32%u6fc0%u52a8%u5242%u6240%u4ea7%u751f%u7684%u7126%u8651%u6548%u5e94%u53ef%u62b5%u6d88 %uff2d%uff2f%uff32%u6fc0%u52a8%u5242%u7684%u6b23%u5feb%u611f%uff0c%u4ece%u800c%u964d%u4f4e%u5404%u79cd%u4f20%u7edf%u963f%u7247%u7c7b%u6210%u763e%u836f%u7269%u7684%u5956%u8d4f%u6548%u5e94%uff3b%uff14%uff14%uff3d%uff0c%u56e0%u6b64 %uff2d%uff2f%uff32%uff0f%uff2b%uff2f%uff32%u53cc%u9776%u70b9%u5316%u5408%u7269%u5728%u5177%u6709%u9547%u75db%u4f5c%u7528%u7684%u540c%u65f6%u5177%u6709%u76f8%u5bf9%u5f31%u7684%u6210%u763e%u526f%u4f5c%u7528%u3002%uff30%uff30%uff2c%ue011%uff11%uff10%uff13%uff08%uff11%uff13%uff0c%u56fe %uff16%uff09%u662f%u4e00%u79cd%u5bf9 %uff2b%uff2f%uff32%u548c %uff2d%uff2f%uff32%u6709%u9ad8%u4eb2%u548c%u529b%u53ca%u90e8%u5206%u6fc0%u52a8%u6d3b%u6027%u7684%u5417%u5561%u5583%u7c7b%u4f3c%u7269%uff0c%u5728%u5c0f%u9f20%u7529%u5c3e%u5b9e%u9a8c%u4e2d%uff0c%uff30%uff30%uff2c%ue011%uff11%uff10%uff13%u7684%u9547%u75db%u6548%u529b%u5927%u7ea6%u662f%u5417%u5561%u7684 %uff11%uff10%u500d%uff3b%uff14%uff15%uff3d%u3002%u540c%u65f6 %uff30%uff30%uff2c%ue011%uff11%uff10%uff13%u4e5f%u5c55%u73b0%u51fa%u4f5c%u4e3a%u6cbb%u7597%u53ef%u5361%u56e0%u4f7f%u7528%u969c%u788d%u6f5c%u5728%u7597%u6cd5%u7684%u7406%u60f3%u7279%u6027%uff3b%uff14%uff16%uff3d%u3002HON13(PPL-103)Ki %u00b5 = 0.36 nmol%u00b7L-1Ki %u03ba =2.47 nmol%u00b7L-1HO O OHNONH214 (MP1207)Ki %u00b5 = 0.23 nmol%u00b7L-1Ki %u03ba = 0.39 nmol%u00b7L-1%uff2b%uff49%u03ba%uff0d%u5316%u5408%u7269%u5bf9 %u03ba%u963f%u7247%u53d7%u4f53%u7684%u7ed3%u5408%u4eb2%u548c%u529b%u3002%u56fe %uff16 %u03bc%u963f%u7247%u53d7%u4f53%uff0f%u03ba%u963f%u7247%u53d7%u4f53%uff08%uff2d%uff2f%uff32%uff0f%uff2b%uff2f%uff32%uff09%u53cc%u9776%u70b9%u6d3b%u6027%u914d%u4f53%uff3b%uff14%uff15%uff0c%uff14%uff17%uff3d%u7814%u7a76%u53d1%u73b0%uff0c%u86cb%u767d%u7ed3%u6784%u4e2d%u8de8%u819c %uff15%u548c%u7ec6%u80de%u5916%u73af%u4e4b%u95f4%u7684%u533a%u57df%u5bf9%u8c03 %u8282 %uff2d%uff2f%uff32%u548c %uff2b%uff2f%uff32%u6291 %u5236 %u86cb %u767d %u52df %u96c6 %u81f3 %u5173 %u91cd %u8981%u3002%u56e0 %u6b64%uff0c%uff35%uff50%uff52%uff45%uff54%uff59%u7b49%uff3b%uff14%uff17%uff3d %u8bbe %u8ba1 %u4e86 %uff2d%uff2f%uff32%uff0f%uff2b%uff2f%uff32 %u53cc %u9776 %u70b9 %u90e8 %u5206 %u6fc0 %u52a8 %u5242%uff2d%uff30%uff11%uff12%uff10%uff17%uff08%uff11%uff14%uff0c%u56fe %uff16%uff09%uff0c%u4e0e%u7b49%u9547%u75db%u5242%u91cf%u7684%u5417%u5561%u76f8%u6bd4%uff0c%u5728%u53d1%u6325%u9547%u75db%u4f5c%u7528%u7684%u540c%u65f6%u5f15%u8d77%u7684%u547c%u5438%u6291%u5236%u4f5c%u7528%u8f83%u5f31%uff0c%u5e76%u51cf%u5c11%u4e86%u9ad8%u6d3b%u52a8%u73b0%u8c61%u7684%u53d1%u751f%u3002%uff12%ue010%uff15 %uff2d%uff2f%uff32%uff0f%u03c3%uff11%uff32%u53cc%u9776%u70b9%u5316%u5408%u7269%u03c3%uff11%uff32%u662f%u4e00%u79cd%u72ec%u7279%u7684 %uff23%uff41%uff12%uff0b%u654f%u611f%u4f34%u4fa3%u86cb%u767d%uff0c%u4e0e%u4efb%u4f55%u5df2%u77e5%u7684%u54fa%u4e73%u52a8%u7269%u86cb%u767d%u6ca1%u6709%u540c%u6e90%u6027%uff0c%u5728%u8d1f%u8d23%u75bc%u75db%u63a7%u5236%u7684%u5173%u952e%u533a%u57df%u4e2d%u5e7f%u6cdb%u8868%u8fbe%uff3b%uff14%uff18%uff3d%u3002%u03c3%uff11%uff32%u901a%u8fc7%u4e0e %uff2d%uff2f%uff32%u3001%uff2b%uff2f%uff32%u3001%u5927%u9ebb%u7d20%u53d7%u4f53%u7b49%u86cb%u767d%u76f8%u4e92%u4f5c%u7528%uff0c%u53c2%u4e0e%u75bc%u75db%u7684%u8c03%u8282%uff3b%uff14%uff19%uff3d%u3002%u7531%u4e8e%u8fd9%u4e9b%u4f34%u4fa3%u86cb%u767d%u5df2%u53c2%u4e0e%u75bc%u75db%u4fe1%u53f7%u7684%u795e%u7ecf%u4f20%u9012%uff0c%u56e0%u6b64 %u03c3%uff11%uff32%u7cfb%u7edf%u88ab%u8ba4%u4e3a%u662f%u75bc%u75db%u7684%u8c03%u8282%u5242%u3002%u4e0e%uff2d%uff2f%uff32%u6fc0%u52a8%u5242%u4e0d%u540c%uff0c%u5728%u751f%u7406%u6761%u4ef6%u4e0b%uff0c%u03c3%uff11%uff32%u62ee%u6297%u5242%u4e0d%u4f1a%u6539%u53d8%u6b63%u5e38%u7684%u75db%u89c9%u9608%u503c%uff0c%u4f46%u4f1a%u964d%u4f4e%u75c5%u7406%u72b6%u6001%u4e0b%u56e0%u4f24%u5bb3%u6027%u611f%u89c9%u7cfb%u7edf%u654f%u5316%u800c%u53d1%u751f%u7684%u5f02%u5e38%u6027%u75bc%u75db%u6216%u75db%u89c9%u8fc7%u654f%uff3b%uff15%uff10%uff3d%u3002%u836f%u7406%u5b66%u548c%u9057%u4f20%u5b66%u6570%u636e%u8868%u660e%uff0c%u03c3%uff11%uff32%u62ee%u6297%u5242%u5728%u81f4%u654f%u6027%u75bc%u75db%u6761%u4ef6%u4e0b%u53ef%u4ea7%u751f%u6297%u75db%u89c9%u8d85%u654f%u4f5c%u7528%uff0c%u5e76%u589e%u5f3a%u963f%u7247%u7c7b%u9547%u75db%u4f5c%u7528%uff0c%u4f46%u4e0d%u589e%u5f3a%u963f%u7247%u7c7b%u836f%u7269%u8bf1%u5bfc%u7684%u4e0d%u826f%u53cd%u5e94%uff0c%u56e0%u6b64%u540c%u65f6%u8c03%u8282 %uff2d%uff2f%uff32%u548c %u03c3%uff11%uff32%u53ef%u4ee5%u63d0%u9ad8%u963f%u7247%u7c7b%u836f%u7269%u7684%u6cbb%u7597%u6548%u679c%u548c%u5b89%u5168%u6027%uff3b%uff15%uff11%ue011%uff15%uff12%uff3d%u3002%uff2d%uff2f%uff32%uff0f%u03c3%uff11%uff32%u53cc%u9776%u70b9%u5316%u5408%u7269%u662f%u8fd1%u5e74%u6765%u65b0%u578b%u9547%u75db%u836f%u7269%u7814%u53d1%u7684%u70ed%u70b9%u65b9%u5411%u4e4b%u4e00%u3002%uff12%uff10%uff12%uff10%u5e74%uff0c%uff21%uff4c%uff4d%uff41%uff4e%uff53%uff41%u7b49%uff3b%uff15%uff13%uff3d%u901a%u8fc7%u836f%u6548%u56e2%u878d%u5408%u6cd5%uff0c%u8bbe%u8ba1%u5e76%u5408%u6210%u00b7%uff12%uff11%uff11%uff10%u00b7 %uff23%uff48%uff49%uff4e%uff30%uff48%uff41%uff52%uff4d%uff2a%uff0c%uff12%uff10%uff12%uff14%uff2e%uff4f%uff56%uff45%uff4d%uff42%uff45%uff52%uff0c%uff36%uff4f%uff4c%ue010%uff15%uff19%uff2e%uff4f%ue010%uff12%uff12 %u4e2d%u56fd%u836f%u5b66%u6742%u5fd7 %uff12%uff10%uff12%uff14%u5e74 %uff11%uff11%u6708%u7b2c %uff15%uff19%u5377%u7b2c %uff12%uff12%u671f