Research progress on the role of thrombospondin 2 in malignant tumors

doi:10.16352/j.issn.1001-6325.2023.12.1881

Abstract

Abstract: Thrombospondin 2 (THBS2) is a matrix cell calcium-binding glycoprotein that interacts with a variety of growth factors, receptors, matrix molecules or proteases on the extracellular matrix and cell surface. THBS2 can be activated by N⁶-methyladenosyl RNA methylase, and mediates tumor proliferation, migration and invasion by remodeling the tumor microenvironment and participating in multiple cell signaling pathways. THBS2 could be used as a diagnostic and prognostic indicator for a variety of tumors, and is expected to become a new target for malignant tumor treatment.

Key words: thrombospondin, thrombospondin 2, carcinoma

CLC Number:

R730.2

MA Jiajunyan, RUI Tiannan, ZHANG Yongsheng. Research progress on the role of thrombospondin 2 in malignant tumors[J]. Basic & Clinical Medicine, 2023, 43(12): 1881-1885.

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