Lentivirus vector in gene therapy of β-thalassemia

doi:10.16352/j.issn.1001-6325.2023.12.1876

Abstract

Abstract: β-thalassemia is a common monogenic inherited blood disorder caused by mutations of β-globin gene which results to synthesis obstacles or abnormal structure of β-globin. Gene therapy mediated by lentiviral vector(LVV) is divided into gene-integration strategies using LVV to add fully functional β-hemoglobin(HBB) genes to chromosomes and gene-editing strategies using LVV to deliver specific ribozymes to hematopoietic stem cells for in situ repair of HBB genes. Improving viral titration and transduction efficiency, reducing target loss and advancing clinical trials are the main targets of these two strategies.

Key words: lentivirus vector, gene therapy, β-thalassemia

CLC Number:

R459.9

LIU Yize, CHAN Ying, ZHU Baosheng. Lentivirus vector in gene therapy of β-thalassemia[J]. Basic & Clinical Medicine, 2023, 43(12): 1876-1880.

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