Abstract: Objective To investigate the expression of signal transducer and activator of transcription 3 (STAT3) in endometrial cancer tissues, and to analyze its relationship with common pathological parameters. Methods The endometrial cancer tissues collected from 45 patients were selected as the observation group, and the para-cancer endometrial tissues sampled from 40 patients were selected as the control group. Immuno-histochemical staining was used to detect the expression of STAT3. The relationship between STAT3 expression and pathological parameters was analyzed. Results The positive rate of STAT3 expression in endometrial cancer tissues was significantly higher than that in paracancer endometrial tissues(P＜0.001). The positive rate of STAT3 expression in endometrial carcinoma tissues with histological grade G2-3 and myometrium invasion＞1/2 was significantly higher than that in endometrial cancer tissues with histological grade G1 and myometrium invasion≤1/2(P＜0.05). Conclusions The expression of STAT3 is significantly increased in endometrial cancer tissues, and is related to the histological grade and myometrium invasion of endometrial cancer, which potentially support the targeted therapy and prognosis assessment of endometrial cancer.

Key words: endometrial carcinoma, signal transducer and activator of transcription 3(STAT3), clinicopathological significance, immunohistochemical staining