Upregulated RAI2 inhibits migration and invasion of endometrial cancer cell lines HEC-1-A and KLE

doi:10.16352/j.issn.1001-6325.2023.10.1537

Abstract

Abstract: Objective To investigate the effect of upregulation of retinoic acid-induced 2 (RAI2) expression on the migration and invasion of endometrial cancer cells. Methods The endometrial cancer cell lines HEC-1-A and KLE were used for this study. Scratch assay and Transwell chamber assay were used to evaluate the migration and invasion of endometrial cancer cells. Immunofluorescence and Western blot were used to detect the expression of RAI2, E-cadherin, and vimentin. Results The upregulation of RAI2 expression in HEC-1-A and KLE cells significantly reduced migration and invasion ability (P＜0.05). The expression levels of RAI2 and E-cadherin were increased, while the vimentin expression level was decreased (P＜0.05). Conclusions Upregulation of RAI2 expression may inhibit endometrial cancer cell migration and invasion through epithelial-mesenchymal transition.

Key words: endometrial cancer, retinoic acid-induced 2(RAI2), migration, invasion

CLC Number:

R711.7

NIE Dan, WANG Chunyan, LI Zhengyu. Upregulated RAI2 inhibits migration and invasion of endometrial cancer cell lines HEC-1-A and KLE[J]. Basic & Clinical Medicine, 2023, 43(10): 1537-1541.

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