| [1] |
Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J]. Nature, 1999, 402: 656-660.
|
| [2] |
Tong J, Dave N, Mugundu GM, et al. The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects[J]. Eur J Endocrinol, 2013, 168: 821-828.
|
| [3] |
Yang Y, Liu R, Qu Y, et al. Ghrelin ameliorates transformation of hepatic ischemia-reperfusion injury to liver fibrosis by blocking Smad and ERK signalling pathways, and promoting anti-inflammation and anti-oxidation effects[J]. Transpl Immunol, 2022, 73: 101597. doi: 10.1016/j.trim.2022.101597.
|
| [4] |
Vázquez MJ, Novelle MG, Rodríguez-Pacheco F, et al. AMPK-dependent mechanisms but not hypothalamic lipid signaling mediates GH-secretory responses to GHRH and Ghrelin[J]. Cells, 2020, 9. doi: 10.3390/cells9091940.
|
| [5] |
Liu X, Guo Y, Li Z, et al. The role of acylated ghrelin and unacylated ghrelin in the blood and hypothalamus and their interaction with nonalcoholic fatty liver disease[J]. Iran J Basic Med Sci, 2020, 23: 1191-1196.
|
| [6] |
Yin Y, Wang Q, Qi M, et al. Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low-grade inflammation via blockade of Kupffer cell M1 polarization[J]. J Cell Physiol, 2021, 236: 5121-5133.
|
| [7] |
Nagoya T, Kamimura K, Inoue R, et al. Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease[J]. Neurogastroenterol Motil, 2020, 32: e13799. doi: 10.1111/nmo.13799.
|
| [8] |
Alharbi S. Exogenous administration of unacylated ghrelin attenuates hepatic steatosis in high-fat diet-fed rats by modulating glucose homeostasis, lipogenesis, oxidative stress, and endoplasmic reticulum stress[J]. Biomed Pharmacother, 2022, 151: 113095. doi: 10.1016/j.biopha.2022.113095.
|
| [9] |
Ezquerro S, Mocha F, Fruhbeck G, et al. Ghrelin reduces TNF-alpha-induced human hepatocyte apoptosis, autophagy, and pyroptosis: role in obesity-associated NAFLD[J]. J Clin Endocrinol Metab, 2019, 104: 21-37.
|
| [10] |
Mao Y, Cheng J, Yu F, et al. Ghrelin attenuated lipotoxicity via autophagy induction and nuclear factor-kappaB inhibition[J]. Cell Physiol Biochem, 2015, 37: 563-576.
|
| [11] |
Elabadlah H, Hameed R, D'Souza C, et al. Exogenous Ghrelin increases plasma insulin level in diabetic rats[J]. Biomolecules, 2020, 10. doi: 10.3390/biom10040633.
|
| [12] |
Lindqvist A, Shcherbina L, Prasad RB, et al. Ghrelin suppresses insulin secretion in human islets and type 2 diabetes patients have diminished islet ghrelin cell number and lower plasma ghrelin levels[J]. Mol Cell Endocrinol, 2020, 511: 110835. doi: 10.1016/j.mce.2020.110835.
|
| [13] |
Adriaenssens AE, Svendsen B, Lam BY, et al. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets[J]. Diabetologia, 2016, 59: 2156-2165.
|
| [14] |
Vestergaard ET, Jessen N, Moller N, et al. Acyl Ghrelin induces insulin resistance independently of GH, cortisol, and free fatty acids[J]. Sci Rep, 2017, 7: 42706. doi: 10.1038/srep42706.
|
| [15] |
Lin Y, Liang Z, He L, et al. Gut Ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway[J]. Cell Commun Signal, 2019, 17: 8. doi: 10.1186/s12964-019-0321-y.
|
| [16] |
Yuan F, Zhang Q, Dong H, et al. Effects of des-acyl Ghrelin on insulin sensitivity and macrophage polarization in adipose tissue[J]. J Transl Int Med, 2021, 9: 84-97.
|
| [17] |
白洁, 张锦妹, 刘丽苹, 等. 生长激素释放肽对糖尿病大鼠视网膜病变的保护作用[J]. 国际眼科杂志, 2021, 21: 1861-1864.
|
| [18] |
Han W, Cui C, Zhang H, et al. Ghrelin ameliorates diabetes-associated behavioral deficits and NLRP3 inflammasome activation via autophagic flux enhancement[J]. Pharmacol Res, 2022, 179: 106224. doi: 10.1016/j.phrs.2022.106224.
|
| [19] |
Atas U, Erin N, Tazegul G, et al. Changes in Ghrelin, substance P and vasoactive intestinal peptide levels in the gastroduodenal mucosa of patients with morbid obesity[J]. Neuropeptides, 2021, 89: 102164. doi: 10.1016/j.npep.2021.102164.
|
| [20] |
Lee JH, Fang C, Li X, et al. GHS-R suppression in adipose tissues protects against obesity and insulin resistance by regulating adipose angiogenesis and fibrosis[J]. Int J Obes (Lond), 2021, 45: 1565-1575.
|
| [21] |
Wasinski F, Barrile F, Pedroso JAB, et al. Ghrelin-induced food intake, but not GH secretion, requires the expression of the GH receptor in the brain of male mice[J]. Endocrinology, 2021, 162. doi:10.1210/endocr/bqab097.
|
| [22] |
Hyland L, Park SB, Abdelaziz Y, et al. Ghrelin infused into the dorsomedial hypothalamus of male mice increases food intake and adiposity[J]. Physiol Behav, 2020, 220: 112882. doi: 10.1016/j.physbeh.2020.112882.
|
| [23] |
Miao H, Pan H, Wang L, et al. Ghrelin promotes proliferation and inhibits differentiation of 3T3-L1 and human primary preadipocytes[J]. Front Physiol, 2019, 10: 1296. doi: 10.3389/fphys.2019.01296.
|
| [24] |
Auclair N, Patey N, Melbouci L, et al. Acylated Ghrelin and the regulation of lipid metabolism in the intestine[J]. Sci Rep, 2019, 9: 17975. doi: 10.1038/s41598-019-54265-0.
|
| [25] |
Péraldi-Roux S, Bayle M, M'Kadmi C, et al. Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin[J]. Biochem Pharmacol, 2022, 202: 115114. doi: 10.1016/j.bcp.2022.115114.
|
