Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage

doi:10.16352/j.issn.1001-6325.2023.03.486

Abstract

Abstract: Subarachnoid hemorrhage (SAH) leads to ferroptosis with clinical evidence like iron metabolism deregulation, increased lipid peroxitation(LPO) and the inhibition of glutathione/glutathione peroxides 4(GSH/GPX4). Ferroptosis mediated early brain injury (EBI) may occur in the 72-hour period following SAH (EBI-SAH) leads to the poor prognosis of SAH. Pharmacological targeting at ferroptosis mitigate EBI-SAH, provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis.

Key words: subarachnoid hemorrhage, early brain injury, ferroptosis, ferroptosis inhibitor

CLC Number:

R743.3

QU Dapeng, SUN Huiyan, LI Qiang, WANG Hongquan. Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage[J]. Basic & Clinical Medicine, 2023, 43(3): 486-489.

References

[1]张敏, 邢丹丹, 康文越, 等. 七氟醚减轻蛛网膜下腔出血大鼠早期脑损伤[J]. 基础医学与临床, 2022,42:1206-1212.
[2]Krishnamurthi RV, Ikeda T, Feigin VL. Global, regional and country-specific burden of ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage: a systematic analysis of the global burden of disease study 2017[J]. Neuroepidemiology, 2020,54:171-179.
[3]Wang W, Jiang B, Sun H, et al. Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based xurvey of 480 687 adults[J]. Circulation, 2017,135:759-771.
[4]Lin F, Li R, Tu WJ, et al. An update on antioxidative stress therapy research for early brain injury after subarachnoid hemorrhage[J]. Front Aging Neurosci, 2021,13:772036. doi: 10.3389/fnagi.2021.772036.
[5]徐娟, 李晔. 铁死亡在阿尔茨海默病中作用的研究进展[J]. 基础医学与临床, 2022,42:1129-1133.
[6]Li Y, Liu Y, Wu P, et al. Inhibition of ferroptosis zlleviates early brain injury after subarachnoid hemorrhage in vitro and in vivo via reduction of lipid peroxidation[J]. Cell Mol Neurobiol, 2021,41:263-278.
[7]Liu Z, Zhou Z, Ai P, et al. Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway[J]. Front Pharmacol, 2022,13:924826. doi: 10.3389/fphar.2022.924826.
[8]Zheng B, Zhou X, Pang L, et al. Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage[J]. Bioengineered, 2021,12:7794-7804.
[9]雷伟, 郝广志, 邹正, 等. 褪黑素抑制早期蛛网膜下腔出血大鼠皮层神经细胞铁死亡[J]. 神经解剖学杂志, 2021,37:454-458.
[10]张红霞, 蒋登志, 车旭东, 等. 依布硒林减轻DMT1诱导的铁死亡在实验性大鼠蛛网膜下腔出血中的研究[J]. 第三军医大学学报, 2017,39:1618-1624.
[11]Zhang H, Ostrowski R, Jiang D, et al. Hepcidin promoted ferroptosis through iron metabolism which is associated with DMT1 signaling activation in early brain injury following subarachnoid hemorrhage[J]. Oxid Med Cell Longev, 2021,2021:9800794.doi: 10.1155/2021/9800794.
[12]Liang Y, Deng Y, Zhao J, et al. Ferritinophagy is involved in experimental subarachnoid hemorrhage-induced neuronal ferroptosis[J]. Neurochem Res, 2022,47:692-700.
[13]Cao Y, Li Y, He C, et al. Selective ferroptosis inhibitor liproxstatin-1 attenuates neurological deficits and neuroinflammation after subarachnoid hemorrhage[J]. Neurosci Bull, 2021,37:535-549.
[14]Kuang H, Wang T, Liu L, et al. Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis[J]. Neurosci Lett, 2021,762:136134. doi: 10.1016/j.neulet.2021.136134.
[15]Huang Y, Wu H, Hu Y, et al. Puerarin attenuates oxidative stress and ferroptosis via AMPK/PGC1α/Nrf2 pathway after subarachnoid hemorrhage in rats[J]. Antioxidants (Basel), 2022,11:1259. doi: 10.3390/antiox11071259.
[16]Lei J, Song S, Chen Z, et al. The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage[J]. Brain Behav, 2022,12:e2722.doi: 10.1002/brb3.2722.
[17]Yuan B, Zhao XD, Shen JD, et al. Activation of SIRT1 alleviates ferroptosis in the early brain injury after subarachnoid hemorrhage[J]. Oxid Med Cell Longev, 2022,2022:9069825. doi: 10.1155/2022/9069825.
[18]Gao SQ, Liu JQ, Han YL, et al. Neuroprotective role of glutathione peroxidase 4 in experimental subarachnoid hemorrhage models[J]. Life Sci, 2020,257:118050.doi: 10.1016/j.lfs.2020.118050.
[19]Qu XF, Liang TY, Wu DG, et al. Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis[J]. CNS Neurosci Ther, 2021,27:449-463.
[20]Gao S, Zhou L, Lu J, et al. Cepharanthine attenuates early brain injury after subarachnoid hemorrhage in mice via inhibiting 15-lipoxygenase-1-mediated microglia and endothelial cell ferroptosis[J]. Oxid Med Cell Longev, 2022,2022:4295208.doi: 10.1155/2022/4295208.
[21]Qu W, Cheng Y, Peng W, et al. Targeting iNOS alleviates early brain injury after experimental subarachnoid hemorr-hage via promoting ferroptosis of M1 microglia and reduc-ing neuroinflammation[J]. Mol Neurobiol, 2022,59:3124-3139.