Abstract: Objective To compare the efficacy and adverse reactions of esophageal cancer patients treated with different radiotherapy doses and concurrent chemotherapy. Methods The subjects of this study were esophageal cancer patients receiving radiotherapy and chemotherapy in Taihe County People's Hospital from March 2020 to March 2022. A total of 40 patients were enrolled and divided into control group (high-dose group, n=20) and experimental group (low-dose group, n=20) by random number table method. The efficacy, adverse reactions and prognosis of the two groups were compared and analyzed. Results After low-dose radiotherapy and chemotherapy, the clinical efficacy of the experimental group was slightly higher than that of the control group, but the difference was not significant. There was no significant difference in SF-36 score and KPS score between the two groups. The total incidence of adverse reaction in experimental group was lower than that in control group(P＜0.05). Conclusions Radiotherapy combined with chemotherapy has a good effect on patients with esophageal cancer and low dose radiotherapy has less adverse reactions and higher safety.

Key words: esophageal cancer, radiation therapy, chemotherapy, adverse reaction