Progress of study on inflammatory factors regulating function of vascular endothelial cells from type 1 diabetes mellitus

Abstract

Abstract: Inflammatory factors are widely involved not only in the physiopathological process of type 1 diabetes mellitus (T1DM), but also in the regulation of vascular endothelial dysfunction. A variety of inflammatory factors affect the insulin signaling pathway through activation of oxidative stress or regulation of related receptors, leading to apoptosis of pancreatic β-cells and vascular endothelial dysfunction. This article reviews the relationship between type 1 diabetes and the inflammatory factors interleukin family, tumor necrosis factor-α, interferon-γ, transforming growth factor β1, and fork head transcription factor p3. Furthermore, the research results on inflammatory factors, soluble vascular cell adhesion molecule (sVCAM), and nuclear factor of activated T cells (NFAT) regulating type 1 diabetes complicated with vascular endothelial dysfunction are reviewed and the potential cytokine immunotherapy modulating vascular endothelial dysfunction is envisioned.

Key words: type 1 diabetes, vascular endothelial cell, inflammatory factors, immunotherapy

CLC Number:

R587.1

LI Qian, LIU Chun-hua, WANG Chen-yi, TAN Jiao-jiao, MA Yu-ping, LYU Hai-hong. Progress of study on inflammatory factors regulating function of vascular endothelial cells from type 1 diabetes mellitus[J]. Basic & Clinical Medicine, 2021, 41(10): 1497-1501.

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