Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (2): 272-276.

• Mini Reviews • Previous Articles     Next Articles

Research progress on the effects of tight junction on lung permeability

WU Xie, YAN Fu-xia*   

  1. Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS & PUMC, Beijing 100037, China
  • Received:2020-01-14 Revised:2020-05-25 Online:2021-02-05 Published:2021-01-19
  • Contact: *yanfuxia@sina.com

Abstract: The alveolar epithelial barrier and the pulmonary microvascular endothelial barrier will be destroyed when the lung tissue is damaged, thus affecting the permeability of the lung and causing serious pulmonary edema. Tight junctions (TJs) are protein complex with “fences and barriers” function that exists in epithelial cells and endothelial cells, and are crucial to the regulation of lung permeability. This paper mainly reviews the research progress on the effects of tight junction proteins on lung permeability, which can deepen the understanding of this problem and provides new ideas for clinical treatment.

Key words: tight junctions, pulmonary permeability, alveolar epithelial barrier, pulmonary endothelial barrier

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