Function of gut microbiota and “gut-lung” axis in sepsis

Abstract

Abstract: Gut microbiota is a large number of microorganisms that colonized in human intestinal tract. The “gut lung” axis is a two-way axis connecting the intestine and the lung. Gut microbiota and “gut lung” axis are involved in the occurrence and development of sepsis. When sepsis occurs, the gut mucosal barrier is damaged, the gut microbiota is imbalance, and bacterial translocation occurs. The lung is the first organ to be effected, and the pulmonary infection may lead to intestinal dysfunction.

Key words: gut microbiota, “gut-lung” axis, bacterial translocation, sepsis

CLC Number:

SHAO Rui-fei, YANG Yan, ZHENG Zhi-rong, ZHAO Shi-min, CHEN Guo-bing. Function of gut microbiota and “gut-lung” axis in sepsis[J]. Basic & Clinical Medicine, 2020, 40(8): 1109-1112.

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