Progress of angiotensin converting enzyme 2 in cardiovascular diseases

Abstract

Abstract: Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV and SARS-CoV-2(severe acute respiratory syndrom coronavirus 2) viruses, and it is also one of the main family members of renin-angiotensin-aldosterone system. ACE2 has a protective effect on cardiovascular diseases and inhibits the development of cardiovascular diseases. SARS-CoV-2 reduces the expression of ACE2 of host, which may be one of the reasons for cardiovascular complications in the later stage of coronavirus disease 2019(COVID-19). Thus, the role and mechanism of ACE2 in the development of cardiovascular diseases were summarized in this article in order to provide potential stratigy development for the treatment of COVID-19.

Key words: angiotensin-converting enzyme 2, cardiovascular diseases, renin-angiotensin-aldosterone system

CLC Number:

JIAO Xiao-lu, QIN Yan-wen. Progress of angiotensin converting enzyme 2 in cardiovascular diseases[J]. Basic & Clinical Medicine, 2020, 40(5): 701-706.

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