Abstract: Chronic kidney disease (CKD) is the persistent state of reno-protective Klotho protein deficiency. The abnormality of klotho epigenetic regulation is regarded as a major cause which reduces the expression of Klotho. Thus, it is important to elucidate the association between the abnormality of klotho epigenetic regulation and Klotho deficiency for reno-protection by targeted regulation of Klotho expression.

Key words: Epigenetic regulation, Klotho, chronic kidney disease