Abstract: Proline-rich protein tyrosine kinase (Pyk2) is a member of the focal adhesion kinase family. Pyk2 is involved in the occurrence, invasion and metastasis of various tumors, including breast and hepatic cancer. It’s also closely related to the prognosis of tumors. To clarify the role of Pyk2 in tumorigenesis and development can provide a theoretical basis for the creation of new anti-cancer targeted drugs.

Key words: proline-rich protein tyrosine kinase (Pyk 2), focal adhesion kinase(FAK), tumors