Abstract: As a member of the forkhead box transcription factor (FOXO) family, FOXO1 is subjected to protein–protein interactions and post-translational modifications such as phosphorylation, acetylation and ubiquitination. FOXO1 can promote the expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), and can bind to the apolipoprotein C-III (ApoC-III) promoter to induce ApoC-III expression and aggravate hypertriglyceridemia. FOXO1 phosphorylation contributes to the promotion of liver microsomal triglyceride transfer protein (MTP) expression and very low density lipoprotein (VLDL) production. The role of FOXO1 in glucose and lipid metabolism in the liver provides a new therapeutic target for insulin resistance and diabetes.

Key words: FOXO1, metabolism, liver