Abstract: Sonodynamic Therapy (SDT) is a novel way to regulate cellular autophagy by increasing intracellular reactive oxygen species (ROS). Autophagy of tumor cells enhances its survival ability and promotes the occurrence of tumor, while autophagy of macrophages can regress the progression of atherosclerotic plaque by reducing the accumulation of lipids and level of inflammation. In this review, the mechanism of SDT induced autophagy and its effects on tumors and atherosclerotic diseases are introduced, and its problems and prospects are pointed out.

Key words: Sonodynamic therapy, autophagy, atherosclerosis, tumors