Abstract: Objective To identify whetherlong-term hyperuricemia is able to induce arota pathological changes in rat. Methods 2%OA forage and 100μmol/L uric acid plus OA lavage were used to copy a long-term hyperuricemia animal model,eNOS,ET-1,ICAM expression in arota was evaluated to find out the role of uric acid in cardiovascular diseases. Results The arotas of hyperuricemia ratshad tiny damages whereas that of rats in control group was totally normal; Hyperuricemia rat had less eNOS expression,moreET-1,ICAM expression in arota(P<0.05) and less NO, more ET-1,ICAM in serum.Conclusions Long-term hyperuricemia is able to induce impairment in endothelium in rat arota, but isn’t able to cause atherosclerosis.

Key words: hyperuricemia, animal model