Abstract: Objective To explore the relation of fat cells factor and insulin resistance in type 2 diabetes. Method We selected 60 patients divided into obesity group, Non-obese group and Normal control group. To detect the FINs, FPG, TG, TC, LDL,HDL,APN,CTRP3,Leptin and TNF-a, according to the formula of HOMA ,to analyze the correlation between indicators. Results 1). Compared with Normal control group, DM group significantly lower serum APN, CTRP3 level, compared with Non-obesity group, obesity group APN, CTRP3 level significantly decreased(p<0.05 or p<0.01). The Leptin levels elevated (p<0.05). 2). The analysis results found that: APN concentration and Age, BMI, FPG, TG, TC, LDL, FINs, HOMA-IR has significant negative correlation; CTRP3 and FPG, FINs, HOMA-negative correlation IR(p<0.05), TG were positively correlated (p<0.05); TNF-a and FPG and positively correlated (p< 0.05).Conclusion:T2DM patients serum APN, CTRP3 and high Leptin levels are closely associated with obesity, HOMA-IR, FPG and TG as an independent factor can be used as a new sensitive index of evaluating the degree of insulin resistance.

Key words: Keywords: Leptin, TNF - a, APN, CTRP3, type 2 diabetes and insulin resistance