Abstract: HACE1 is not only an important tumor suppressor gene, which plays an important role in tumor inhibition by mediating cell autophagy, Rac1 ubiquitination and other mechanisms, but also involved in a variety of biological functions about heart protection, anti-oxidative stress and cellular dynamics. Downregulation or mutations of HACE1 gene plays an important role in many human malignancies occurrence, invasion and metastasis process and closely related to prognosis. Therefore, HACE1 may become a new target for cancer therapy, providing new directions and opportunities for treatment of malignant tumors.

Key words: HACE1, tumor suppressor gene, malignant tumor