Abstract: Non-alcoholic steatohepatitis (NASH) is recognized as the most severe form of non-alcoholic fatty liver disease (NAFLD), with likely progression to liver cirrhosis and hepatocellular carcinoma. Vitamin D3 (VD3) has been shown to act as anti-oxidant, anti-apoptotic, anti-inflammatory and anti-fibrotic compound in rodents. VD3 supplementation partly ameliorated the NASH progression. VD3 can be an effective approach for the intervention in clinical NASH.

Key words: Vitamin D3, non-alcoholic steatohepatitis