Abstract: Mucin-2 (MUC2), secreted by goblet cells of the intestine, covers the gastrointestinal tract and is the most abundantly expressed mucin in the mucus layer. It contains high concentrations of antibacterial peptides and proteins, which protects the epithelium against noxious agents, viruses, and pathogenic bacteria. In recent years the role of MUC2 on the intestinal mucosal barrier dysfunction get more and more attention, which may also be an important breakthrough in the treatment of intestinal mucosal barrier damage.

Key words: mucin2, goblet cells, mucus layer, intestinal mucosal barrier