Abstract: Objective: To study the clinical characteristics of pure androgen-producing adrenal adenoma. Method: Clinical data from 7 cases with pure androgen-producing adrenal adenoma treated in PUMCH from 2002 to 2014 were analyzed retrospectively. Results：Seven patients with age at onset from 3.5 to 31 years had various clinical courses from 1.5 to 30 years. All female patients (n=6) had virilism and one male patient developed sexual precocity. Serum testosterone levels were 4.1-33.0 nmol/L preoperatively and in the females decreased to 0.1-1.3nmol/L postoperatively accompanying with relief of the symptoms, and decreased to 4.1mmol/L for the boy because of secondary central precocious puberty. All the tumors were histologically diagnosed with adrenocortical adenoma. Conclusions: Pure androgen-producing adrenal adenoma usually occurs in childhood. Clinical characteristics are various according to the sex and age of the patients. Androgen-producing adrenal adenoma should be suspected when the patients develop virilism, menstrual disorder, or sexual precocity.

Key words: Adrenal adenoma, Hyperandrogenemia, Clinical characteristics, Treatment