Abstract: Objective In the study we mainly aimed to execute frame-work based learning in the teaching of Medical Microbiology and make a preliminary exploration of its potential populization in other fields of medical sciences. Methods In the reform of medical education, the teaching of Medical Microbiology was partly integrated with Medical English and frame-work based learning model was involved. In the study, 307 third grade students in Peking Union Medical College were successively enrolled in the practice of this reform of frame-work based learning in the former term. Underlying this frame-work based learning, students were encouraged to: base their learning target on the practical application, design frame-works according to their professional requirements or learning targets, and organize self regulated learning in groups. Anonymous questionnaires were used to evaluate the subjective feelings of students. And simultaneously, the percentage distribution of topics of all self learning groups involved in self regulated learning was analyzed and compared. Results Percentages of topics involved in non-Medical Microbiology curriculums in medical sciences were respectively 21.43% in Grade 2008,7.14% in Grade 2009, 38.89% in Grade 2008 and 57.14% in Grade 2011. Conclusion Frame-work based learning exhibits a potential populization in learning of other medical courses.

Key words: Key words: frame-work based learning, self-regulated learning, potential populization