Abstract: Objective Through summarizing cases, analyze the characteristics of acute coronary syndrome patients in myeloproliferative neoplasms (MPN) population, and investigate the association factors of acute coronary syndrome (ACS). Methods In total 125 cases of hospitalized patients diagnosed of MPN in Peking Union Medical College Hospital in 2004-2014 were included in this study. The information of demographic data (age, gender), cardiovascular risk factors (smoking, hypertension, hyperlipidemia, diabetes), previous history of thrombosis, previous history of coronary artery disease, previous history of other peripheral vascular disease, previous hydroxyurea or anti-platelet therapy, and laboratory parameters (complete blood count, coagulation functions) was collected and further analyzed for basic characteristics of ACS cases; Spearman correlation analysis was applied to explore association factors of acute coronary syndromes. Results A total of 7 cases developed ACS (incidence 5.6%). Between ACS and non-ACS patients, significant difference existed in previous history of coronary artery disease (18.6% vs. 85.7%, p<0.001, hemoglobin level (141±45 vs. 171±13, p<0.001) and leukocyte count (10.76±8.09 vs. 17.88±8.79, p<0.05). Spearman analysis found significant positive correlations between ACS and previous history of coronary artery disease and leukocyte count (correlation coefficients were 0.361, 0.271, respectively; p<0.05). Conclusion ACS was one of the major thrombosis complications in MPN population. Previous history of coronary artery disease and leukocytosis probably associated with ACS in MPN population.

Key words: myeloproliferative neoplasms, acute coronary syndrome