Abstract: Renal proximal epithelial cells contain multiple urate transporters, which could be categorized into reabsorption related, excretion related and skeleton proteins by function. Urate transporter 1, glucose transporter 9 and ATP-binding cassette family G subfamily type 2 are the three most important transporters; while PDZK1 provides structural support for other transporters. These urate transporters are the linkage of hyperuricemia and other metabolic disorders, as well as the promising target of new urate lowering therapies.

Key words: urate, urate transporter, urate-lowering therapy