Abstract: RhoA/ROCK signaling pathway is ubiquitously involved in regulation of actin cytoskeleton and various cell behaviors, including cell contraction, adhesion, proliferation, gene expression, and so on. In the past few decades, accumulating experimental and clinical evidences suggest it plays an important role in atherosclerosis. Thus, revealing the molecular mechanisms and inhibition of RhoA/ROCK pathway will undoubtedly deepen our understanding of cardiovascular disease and even maybe a promising therapeutic target.

Key words: rhoA GTP-Binding Protein，rho-Associated Kinases，atherosclerosis, molecular mechanism