Abstract: Recent studies have shown that regulation of Nrf2/ARE/HO-1 confer neuroprotection against oxidative stress-induced neurotoxicity. The specific activation of Nrf2/ARE/HO-1 gene expression by pharmacological modulation may represent a novel approach for therapeutic treatment of PD. There is, therefore, an excellent rationale for the development of new neuroprotective agents, based on their ability to enhance activity of Nrf2 and upregulate HO-1 expression.

Key words: Nrf2, Heme oxygenase-1, Parkinson’s disease, Neuroprotection