Abstract: The CCN family consists of six members, namely Cyr61(CCN1), CTGF(CCN2), NOV(CCN3), WISP-1(CCN4), WISP-2(CCN5) and WISP-3(CCN6). Extensive research shows that the CCN family plays an important role in the process of fibrosis. As fibrotic inhibitors, CCN1, CCN3 and CCN5 could inhibit fibrosis; while as fibrotic promoting factors, CCN2 and CCN4 could promote fibrosis.

Key words: CN family, gene expression, fibrosis