Abstract: Collapsin response mediator protein 2(CRMP2) plays a crucial role in neuronal development. It owns lots of post-translational modifications, of which phosphorylation modification is related to diseases closely. CRMP2 also has many biological functions. There is a close relationship between CRMP2 and neurologic disorders, but the mechanism is required to be elucidated. The researches in CRMP2 provided new strategies to prevent and cure the related diseases.

Key words: CRMP2, Phosphorylation, Alzheimer's Disease, Hypoxia-Ischemia Injury, Psychosis