Abstract: The axon guidance molecule Slit3 is a secreted extracellular matrix protein that was found in recent years. Genetic function studies revealed that Slit3 is dispensable for neural development but required for non-neuron-related developmental. Recent study suggests that Slit3 is a new angiogenic factor implicated in regulating a variety of life activities, such as cell migration, angiogenesis, organogenesis, reproductive regulation, tumourigenesis and mental disease.

Key words: axon guidance molecule, Slit3, cell migration, angiogenesis, organogenesis