Abstract: Abstract: Objective To investigate the relationship between polymorphisms of rs10811661 in CDKN2A/2B gene and gestational diabetes. Methods The 100 normal glucose tolerance pregnant women, 120 gestational diabetes patients and 100 type 2 diabetes patients living in the southwest of Shandong Province were recruited. Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism, we determined the genotypes of rs1081166 in CDKN2A/2B. Results There were significant difference in genotypic TT, TC ,CC and risk allele T frequency of CDKN2A/2B rs10811661 between NGT group and GDM group(P=0.005, 0.012respectively). So did the difference between NGT group and T2DM group(P=0.014, 0.015 respectively）.But there were no difference between GDM group and T2DM group. Conclusion The rs10811661 T/C polymorphisms of CDKN2A/2B gene may be related with the gestational diabetes patients in the the southwest of Shandong Province.

Key words: gestational diabetes mellitus, gene, polymorphism, CDKN2A/2B