Expression of Slitrk6 during testicular tissue development in rats

doi:10.16352/j.issn.1001-6325.2025.07.0912

Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (7): 912-917.doi: 10.16352/j.issn.1001-6325.2025.07.0912

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Expression of Slitrk6 during testicular tissue development in rats

LIU Shanshan^1#, BAI Jie^1#, WANG Xueying¹, GAO Lin¹, ZHANG Yan¹, LIU Taodi^1*, ZHANG Xinlai^2*

1. Laboratory of Medical Neurobiology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110;
2. Department of General Surgery, Affiliated Hospital of Inner Mongolia Medical University; Hohhot 010110, China

Received:2025-02-13 Revised:2025-04-23 Online:2025-07-05 Published:2025-06-24
Contact: ^*taodiliu@163.com;sdxinlaizhang@163.com

Abstract

Abstract: Objective To investigate the transcriptional and translational expression of Slitrk6 in rat spermatogenesis. Methods The mRNA transcription level and translation level of Slitrk6 were detected by RT-qPCR and Western blot, respectively in testis of rats aged 2-65 days (repeat three times at each time point). Results The mRNA expression of Slitrk6 reached the highest on day 4 and day 10. SLITRK6 protein was continuously expressed during testis development in rats. Slitrk6 was found in human testis through PPI network. Conclusions Slitrk6 is potentially involved in mitosis and meiosis in spermatogenesis; The Slitrk6 may be one of the key genes in spermatogenesis. SLITRK6 protein is involved in mitosis and the transformation of round spermatids.The results lay a foundation for subsequent research on male infertility.

Key words: male infertility, testicular tissue, Slitrk6, spermogenesis

CLC Number:

Q492

LIU Shanshan, BAI Jie, WANG Xueying, GAO Lin, ZHANG Yan, LIU Taodi, ZHANG Xinlai. Expression of Slitrk6 during testicular tissue development in rats[J]. Basic & Clinical Medicine, 2025, 45(7): 912-917.

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Expression of Slitrk6 during testicular tissue development in rats

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[1]	Zhou-cun A; Li XU. Deletion of gr/gr-DAZ1/DAZ2 gene and male infertility [J]. Basic & Clinical Medicine, 2009, 29(9): 905-907.
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