Abstract: Objective: To explore the soluble cluster of differentiation antigen 14(sCD14) dynamic changes and clinical significance on patients with sepsis. Methods: 60 patients were diagnosed with sepsis according to the diagnosis criterions and selected as sepsis group from the emergency intensive care unit of Chaoyang Hospital affiliated Capital Medical University during the period from August 2009 to March 2010. 20 healthy persons were chosen as control group. Sepsis group was divided into multiple organ dysfunction syndrome (MODS) and non-MODS two subgroups according to MODS clinical diagnosis criterions. sCD14 concentration was detected and APACHEⅡscore were calculated on 1st , 3rd and 7th days after the patients were diagnosed sepsis in sepsis group. Results: Compared with control group, sCD14 concentration was obviously higher in sepsis group（P<0.01）. Compared with non-MODS subgroup, MODS subgroup has more higher sCD14 concentration [（5.3±2.4）vs （3.8±2.8）μg/mL P<0.05 ]and APACHEⅡscores( P<0.05). sCD14 concentration and APACHEⅡ scores had correlation( P<0.05). Conclusions: sCD14 concentration was high on patients with sepsis. MODS patients had high sCD14 concentration and APACHEⅡ scores, patients condition were more critical.

Key words: Sepsis, multiple organ dysfunction syndrome, sCD14, APACHEⅡ score