Abstract: ABSTRACT Objective To investigate the role of p38MAPK in the expression of β-Amyloid precursor protein (APP) and it’s epigenetic mechanisms. Methods Cultured SH-SY5Y cells were used to test the expression of APP, histone acetyltranferase (HAT) and histone deacetyltranferase (HDAC) by Western blot after activation of p38MAPK; Acetylation level of histone H3 andH4 were examined by optical density assay. Results APP expression was increased after p38MAPK activation for 72 hours compared to the control. Levels of histone H3 acetylation were increased accompanied with up-regulation of CBP and down-regulation of HDAC3. Conclusion APP Expression could be increased by up-regulation of Histone Acetylation through p38MAPK Pathway.

Key words: p38MAPK, Histone Acetylation, β-amyloid precursor protein, Alzheimer’s disease