Research progress in the treatment of NLRP3 inflammasome-mediated pyroptosis in cerebral ischemia-reperfusion injury

doi:10.16352/j.issn.1001-6325.2026.03.0435

Abstract

Abstract: Cerebral ischemia-reperfusion injury (CI/RI) is an important cause of neurological deterioration after ischemic stroke, and its mechanism is related to pyroptosis mediated by NLRP3 inflammasomes. The NLRP3 inflammasome is activated under the influence of multiple pathological mechanisms, promoting caspase-1-dependent gasdermin D lyses, triggering the formation of cell membrane pores and the release of inflammatory factors (IL-1β, IL-18), thereby leading to the occurrence of pyroptosis. Pyroptosis, as a type of cell death with obvious inflammatory response characteristics, It will cause and exacerbate neuroinflammatory responses.

Key words: NOD-, LRR-and pyrin domain-containing protein 3(NLRP3), pyroptosis, cerebral ischemia-reperfusion injury

CLC Number:

R743

YANG Yiwei, SUN Xiaowei. Research progress in the treatment of NLRP3 inflammasome-mediated pyroptosis in cerebral ischemia-reperfusion injury[J]. Basic & Clinical Medicine, 2026, 46(3): 435-439.

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