Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (12): 1657-1661.doi: 10.16352/j.issn.1001-6325.2025.12.1657

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Role of SP1 phosphorylation in development of tumor

XIAO Chengpu1, SUN Xutao2, SONG Yunjia3, XIE Ying2, JIANG Deyou2*   

  1. 1. Internal Medicine of Traditional Chinese Medicine, Grade 2023, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040;
    2. Clinical Foundation of Chinese Medicine Teaching and Research Group; 3. Pharmacology Teaching and Research Group, School of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China
  • Received:2024-12-30 Revised:2025-04-28 Online:2025-12-05 Published:2025-11-25
  • Contact: *jiangdeyou@126.com

Abstract: Phosphorylation is a common post-translational modification of specific protein 1(SP1), which can affect its transcriptional activity and DNA-binding stability by altering the structure of SP1. Phosphorylation of SP1 can promote telomere maintenance, immune escape, and production of vascular endothelial growth factor in cancer cells, promote tumor invasion and metastasis, and increase drug resistance to chemotherapy.

Key words: specificity protein 1, phosphorylation, protein kinase

CLC Number: