Research progress on the role of Asprosin in germ cell development

doi:10.16352/j.issn.1001-6325.2024.04.0558

Abstract

Abstract: Asprosin is a protein-like hormone composed of 140 amino acids, which is mainly secreted by adipocytes. Polycystic ovary syndrome(PCOS) and asthenospermia are common causes of infertility. Asprosin promotes the production of estradiol in small granular cells induced by follicle stimulating hormone(FSH )and progesterone in small granular cells induced by insulin-like growth factor 1(IGF-1), which functions in the growth of ovarian follicles and ovulation of dominant follicles. Asprosin promotes the secretion of sex hormones and the production of nutrients, increasing the number, survival time and motility of sperms by acting on the hypothalamus and testicles. Asprosin is involved in regulation of follicle growth and spermatogenesis, so this finding may potentially support the development of new strategies for the treatment of infertility.

Key words: Asprosin, polycystic ovary syndrome(PCOS), germ cell

CLC Number:

XU Zhiqin, TAN Xiao. Research progress on the role of Asprosin in germ cell development[J]. Basic & Clinical Medicine, 2024, 44(4): 558-561.

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