Long non-coding RNA and diseases

doi:10.16352/j.issn.1001-6325.2024.10.1465

Abstract

Abstract: Long non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation. They are widely involved in epigenetics, transcription, translation, modification and degradation, thereby affecting the life activities of the body, and their expression imbalance is closely related to the occurrence and development of diseases. Therefore, analyzing the inherent characteristics of lncRNA and revealing its intrinsic role can not only deepen our understanding of human physiological and pathological processes, but also provide new ideas and potential solutions for the diagnosis, prevention and treatment of diseases. So as to provide references for the related research of lncRNAs.

Key words: non-coding RNA, tumors, nervous system, disease, epigenetics

CLC Number:

R456

References

[1]Liang J, Liu C, Xu D, et al. LncRNA NEAT1 facilitates glioma progression via stabilizing PGK1[J]. J Transl Med, 2022,20:80. doi: 10.1186/s12967-022-03273-2.
[2]Guo CJ, Ma XK, Xing YH, et al. Distinct processing of lncRNAs contributes to non-conserved functions in stem cells[J]. Cell, 2020,181:621-636.e22. doi:10.1016/j.cell.2020.03.006.
[3]Srinivas T, Siqueira E, Guil S. Techniques for investigat-ing lncRNA transcript functions in neurodevelopment[J].Mol Psychiatry, 2024,29:874-890. doi:10.1038/s41380-023-02377-5.
[4]Hashemi M, Moosavi MS, Abed HM, et al. Long non-coding RNA (lncRNA) H19 in human cancer: from proliferation and metastasis to therapy[J]. Pharmacol Res, 2022,184:106418. doi:10.1016/j.phrs.2022.106418.
[5]Sur S, Ray RB. Emerging role of lncRNA ELDR in development and cancer[J]. FEBS J, 2022,289:3011-3023. doi:10.1111/febs.15876
[6]Han J, Yu X, Wang S, et al. IGF2BP2 induces U251 glioblastoma cell chemoresistance by inhibiting FOXO1-mediated PID1 expression through stabilizing lncRNA DANCR[J]. Front Cell Dev Biol, 2021,9:659228. doi:10.3389/fcell.2021.659228.
[7]Liu J, Zhu Y, Wang H, et al. LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc[J]. Cancer Sci, 2024,115:804-819. doi:10.1111/cas.16049.
[8]Sui H, Shi C, Yan Z, et al. LRRC75A-AS1 drives the epithelial-mesenchymal transition in cervical cancer by binding IGF2BP1 and inhibiting SYVN1-mediated NLRP3 ubiquitination[J]. Mol Cancer Res, 2024. doi:10.1158/1541-7786.MCR-23-0478.
[9]王春燕, 王萍, 宋龙飞, 等. LncRNA FEZF1-AS1通过调控EZH2对肺间质细胞增殖、迁移及侵袭的作用[J]. 基础医学与临床, 2024,44:43-50.
[10]Yu X, Qian F, Zhang X, et al. Promotion effect of FOXCUT as a microRNA sponge for miR-24-3p on progression in triple-negative breast cancer through the p38 MAPK signaling pathway[J]. Chin Med J (Engl), 2024,137:105-114. doi:10.1097/CM9.0000000000002700.
[11]Su L, Zhang Y, Wang Y, et al. Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer's Disease[J]J Integr Neurosci, 2023,22:136. doi:10.31083/j.jin2206136.
[12]Zhang Y, Tang L, Wang Y, et al. In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25[J]. Neuroreport, 2024,35:49-60. doi:10.1097/WNR.0000000000001977.
[13]Balusu S, Horre K, Thrupp N, et al. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease[J].Science,2023,381:1176-1182. doi:10.1126/science.abp9556.
[14]Elkouris M, Kouroupi G, Vourvoukelis A, et al. Long non-coding RNAs associated with neurodegeneration-linked genes are reduced in Parkinson's disease patients[J]. Front Cell Neurosci, 2019,13:58. doi:10.3389/fncel.2019.00058.
[15]Zhang QS, Wang ZH, Zhang JL, et al. Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting alpha-synuclein protein expression[J]. Biomed Pharmacother, 2016,83:153-159. doi:10.1016/j.biopha.2016.06.017.
[16]Chen S, Zhu X, Niu W, et al. Regulatory role of lncRNA NONHSAT089447 in the dopamine signaling pathway in schizophrenic patients[J]. Med Sci Monit, 2019,25:4322-4332. doi:10.12659/MSM.915684.
[17]Qi Y, Wei Y, Yu F, et al. Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese[J]. BMC Psychiatry, 2021,21:613. doi:10.1186/s12888-021-03623-2.
[18]Teng P, Li Y, Ku L, et al. The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases[J]. Brain Behav Immun, 2023,112:175-187. doi:10.1016/j.bbi.2023.06.009.
[19]Li X, Wu X, Li W, et al. HERV-W ENV induces innate immune activation and neuronal apoptosis via linc01930/cGAS axis in recent-onset schizophrenia[J]. Int J Mol Sci, 2023,24. doi:10.3390/ijms24033000.
[20]Li Y, Wang YX, Tang XM, et al. Haplotype analysis of long-chain non-coding RNA NONHSAT102891 promoter polymorphisms and depression in Chinese individuals: a case-control association study[J]. World J Psychiatry, 2023;13:1005-1015. doi:10.5498/wjp.v13.i12.1005.
[21]Wang X, Memon AA, Hedelius A, et al. Circulating mitochondrial long non-coding 7S RNA in primary health care patients with depression/anxiety[J]. J Affect Disord, 2024,349:101-106. doi:10.1016/j.jad.2023.12.053.
[22]Chen HS, Wang J, Li HH, et al. Long noncoding RNA Gm2694 drives depressive-like behaviors in male mice by interacting with GRP78 to disrupt endoplasmic reticulum homeostasis[J]. Sci Adv, 2022,8:n2496. doi:10.1126/sciadv.abn2496.
[23]Xu H, Brown AN, Waddell NJ, et al. Role of long noncoding RNA Gas5 in cocaine action[J]. Biol Psychiatry, 2020,88:758-766. doi:10.1016/j.biopsych.2020.05.004.
[24]Van Booven D, Mengying L, Sunil R J, et al. Alcohol use disorder causes global changes in splicing in the human brain[J]. Transl Psychiatry, 2021,11:2. doi:10.1038/s41398-020-01163-z.
[25]Muenstermann C, Clemens KJ. Epigenetic mechanisms of nicotine dependence[J]. Neurosci Biobehav Rev, 2024,156:105505. doi:10.1016/j.neubiorev.2023.105505.