Serum IFN-γ is increased in patients with active vitiligo

doi:10.16352/j.issn.1001-6325.2022.07.1067

Abstract

Abstract: Objective To examine serum C-reactive protein (CRP), tumor necrosis factor-α(TNF-α), tumor necrosis factor-β(TNF-β), E-cadherin (E-cad), human interferon-γ (IFN-γ) and cluster of differentiation 8 (CD8) in patients with vitiligo. Methods From May 2017 to December 2018, 60 patients with vitiligo (30 cases in active phase group and 30 cases in stable stage group) and 30 cases as control group collected from physical examination center joined the research program. The content of serum CRP, TNF-α, TNF-β, E-cad, IFN-γ and CD8 were compared among the three groups by enzyme-linked immunosorbent assay (ELISA). Results The content of serum CRP, TNF-α, TNF-β and IFN-γ in patients with active and stable vitiligo were significantly higher(P＜0.05). The content of serum IFN-γ in patients with active vitiligo was significantly higher than that in patients with stable vitiligo(P＜0.05)and significantly decreased after 6 months of treatment(P＜0.05). Conclusions The content of serum IFN-γ might be used as a biomarker in laboratory to evaluate the activity of vitiligo.

Key words: vitiligo, cytokines, active stage, pathogenesis

CLC Number:

R446.11

ZHAO Xiao-ling, HE Run-zhi, SUN Yu-jiao, ZHANG Xiao-chong, YANG Lin-fang, WANG Rui, CHENG Fang. Serum IFN-γ is increased in patients with active vitiligo[J]. Basic & Clinical Medicine, 2022, 42(7): 1067-1070.

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