Role of Tamm-Horsfall protein in acute kidney injury

doi:10.16352/j.issn.1001-6325.2022.11.1795

Abstract

Abstract: The Tamm-Horsfall protein (THP), also known as uromodulin (UMOD), is a kidney-derived protein released bidirectionally in the blood and urine. Blood and urinary THP may be markers of early predictive diagnosis of acute kidney injury(AKI) and possibly as one of the indicators of AKI severity. At the same time, THP plays a role in protecting kidney function in AKI through inhibiting reactive oxygen species accumulation, anti-inflammatory response and regulating macrophages. So it is a potential target in the clinical treatment of AKI.

Key words: Tamm-Horsfall protein, uromodulin, acute kidney injury

CLC Number:

R692

XU Yi-wen, LI Qing-chu. Role of Tamm-Horsfall protein in acute kidney injury[J]. Basic & Clinical Medicine, 2022, 42(11): 1795-1798.

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