Research progress on molecular mechanism of the interaction between autophagy and apoptosis

Abstract

Abstract: Autophagy and apoptosis are two different physiological phenomena, however they are closely related in function. This paper introduces the classification and process of autophagy and apoptosis, and discusses the effects of some key regulatory proteins in the formation of autophagosome and the dual role of apoptosis and anti-apoptosis proteins on autophagy and apoptosis, so as to explore the relationship between autophagy and apoptosis, and to provide theoretical basis for further study of autophagy and apoptosis related diseases.

Key words: molecular mechanism, autophagy-related gene(Atg), caspase

CLC Number:

R329

ZHANG Yang, SUN Wan-wan, LU Li-dan, FENG Xiao-ling. Research progress on molecular mechanism of the interaction between autophagy and apoptosis[J]. Basic & Clinical Medicine, 2021, 41(9): 1342-1346.

References

[1]Maria Z, IZachari M, Ganley IG. The mammalian ULK1 complex and autophagy initiation[J]. Essays Biochem, 2017, 61: 585-596.
[2]Mcknight NC, Yue Z. Beclin 1, an essential component and master regulator of PI3K-Ⅲ in health and disease[J]. Curr Pathobiol Rep, 2013, 1: 231-238.
[3]Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018[J]. Cell Death Differ, 2018, 25: 486-541.
[4]Nagata S. Apoptosis and clearance of apoptotic cells[J]. Annu Rev Immunol, 2018, 36: 489-517.
[5]Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade[J]. Cell, 1997,91: 479-489.
[6]Delgado M, Tesfaigzi Y. BH3-only proteins, Bmf and Bim, in autophagy[J]. Cell Cycle, 2013, 12: 3453-3454.
[7]Kuma A, Komatsu M, Mizushima N. Autophagy-monitoring and autophagy-deficient mice[J]. Autophagy. 2017, 13: 1619-1628.
[8]Lepine S, Allegood JC, Edmonds Y, et al. Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage[J]. J Biol Chem, 2011, 286:44380-44390.
[9]Ma X, Liu Y, Muhammad W, et al. Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss[J]. Mol Med Rep, 2017, 15: 3819-3825.
[10]Tsapras P, Nezis IP. Caspase involvement in autophagy[J]. Cell Death Differ, 2017, 24: 1369-1379.
[11]Julien O, Wells JA. Caspases and their substrates[J]. Cell Death Differ, 2017, 24: 1380-1389.
[12]Xiao B, Deng X, Lim GG Y, et al. p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization[J]. Biochim Biophys Acta Mol Cell Res, 2017, 1864: 1308-1317.
[13]Booth LA, Tavallai S, Hamed HA, et al. The role of cell signalling in the crosstalk between autophagy and apoptosis[J]. Cell Signal, 2014, 26: 549-555.
[14]徐凌珂. 分子伴侣介导的自噬通过降解PLIN2改善棕榈酸诱导的足细胞脂质集聚和凋亡[D]. 重庆:重庆医科大学, 2019:20-26.
[15]Tummers B, Green DR. Caspase-8: regulating life and death[J]. Immunol Rev, 2017, 277: 76-89.
[16]Rubinstein AD, Kimchi A. Life in the balance-a mechanistic view of the crosstalk between autophagy and apoptosis[J]. J Cell Sci, 2012, 125: 5259-5268.
[17]Smyth P, Sessler T, Scott CJ, et al. FLIP (L): the pseudo-caspase[J]. FEBS J, 2020:1-15
[18]Castrogiovanni C, Waterschoot B, De Backer O, et al. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis[J]. Cell Death & Differentiation, 2018, 25: 190-203.
[19]Kruse JP, Gu W. Modes of p53 Regulation[J]. Cell, 2009, 137: 609-622.
[20]Denisenko TV, Pivnyuk AD, Zhivotovsky B. p53-autophagy-metastasis link[J]. Cancers, 2018, 10: 148: 1-20.
[21]Marino G, Niso-Santano M, Baehrecke EH, et al. Self-consumption: the interplay of autophagy and apoptosis[J]. Nat Rev Mol Cell Biol, 2014, 15: 81-94.