Abstract: Objective To evaluate the usefulness of RHBDD1, pepsinogen(PGI and PGII) and CEA in screening atrophic gastritis, and to evaluate the value of them in early diagnosis of gastric cancer. Method We collected 78 patients from January 2016 to January 2017 who underwent gastroscopy and pathological examination of gastric mucosa in Beijing Hospital. They were divided into five groups according pathological results: CSG11cases, CAG18 cases, LGIN10 cases, EGC23 cases, AGC16 cases. Serum CEA, pepsinogen and RHBDD1 of the patients were measured. Then all the results were analysed by using SPSS19.0. Results The levels of PGⅠ/Ⅱ were statistically significant different among 5 groups (p＜0.05).There were statistical differences in comparing of CSG-EGC、CSG-AGC、CAG-AGC and LGIN-AGC groups (p＜0.05). Levels of CEA and PGⅠ/Ⅱ among gastritis, early gastric cancer and advanced gastric cancer were statistically different as well（p＜0.05）, a RHBDD1 was in ascending trend among these three groups. Conclusions Low level of PGⅠ/Ⅱ can be used in screening and early diagnosis of gastric cancer.

Key words: atrophic gastritis, gastric cancer, CEA, RHBDD1, pepsinogen