Abstract: Cisplatin，as a first-line clinical cancer chemotherapy drug，because of its poor treatment options，when killing the target cells it can have cytotoxicity effects on the normal tissue and cells，leading the women cancer patients of gestational age to ovarian dysfunction involved，causing adverse reactions such as premature ovarian failur and infertility. Cisplatin can activate ovarian cell apoptosis，oxidative stress response and multiple signaling pathways through the interaction of more factors to induce ovarian damage. How to effectively prevent or eliminate the damage of ovarian failure caused by chemotherapy drugs has caused widespread concern and research in the medical field.

Key words: Key word：cisplatin, chemotherapy, premature ovarian failure