Abstract: Mitochondrial fusion、fission and dynamic transformation between the two are commonly known as mitochondrial dynamics. Mitochondrial fusion-fission is related to a variety of biological functions of mitochondria, including regulation of energy metabolism, production of reactive oxygen species, m aintenance of Ca2+ homeostasis and influence of cellular death.It is reported that cardiac development、energy metabolism and ion homeostasis are closely related to the balance of mitochondrial fusion-fission.Mitochondrial fusion-fission disorders could cause myocardial cell dysfunction、damage and even the death of myocardial cells, which result in heart failure ultimately. Developing drugs aiming to reconstruct the balance of mitochondrial fusion-fission may provide new ideas and strategies for the treatment of chronic heart failure.

Key words: Key words: Mitochondria, Fusion, Fission, Heart failure